A conformational study of normal and dicoumarol-induced prothrombin
نویسندگان
چکیده
منابع مشابه
Vitamin K and the biosynthesis of prothrombin. II. Structural comparison of normal and dicoumarol-induced bovine prothrombin.
Highly purified dicoumarol-induced bovine prothrombin, which does not bind calcium ions and has no prothrombin activity, has been structurally compared with normal prothrombin. Quantitative amino acid and carbohydrate analysis gave identical results for both prothrombins, as did analysis of the NHz-terminal and the COOH-terminal amino acids and molecular weight determination with the sodium dod...
متن کاملProthrombin Time in Dicoumarol Therapy.
In the course of controlling dicoumarol therapy given (a) as a postoperative routine to prevent thrombosis (fifty-five cases) and (b) therapeutically in cases of established venous thrombosis (nine cases), certain peculiarities have been observed in the behaviour of the prothrombin time, particularly in relation to dicoumarol haemorrhage. Two sources of thromboplastin have been used, Russell vi...
متن کاملVitamin K and the biosynthesis of prothrombin. IV. Isolation of peptides containing prosthetic groups from normal prothrombin and the corresponding peptides from dicoumarol-induced prothrombin.
The 25,000 Af, fragment obtained by thrombin digestion of normal prothrombin has been further compared with the corresponding fragment from dicoumarol-induced prothrombin. In contrast with the fragment from normal prothrombin, the one from dicoumarol-induced prothrombin does not bind calcium (STENFLO, J. (1973) /. Biol. Chem. 248, 6325). After cyanogen bromide degradation of this material, a fr...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1973
ISSN: 0014-5793
DOI: 10.1016/0014-5793(73)80869-5